Analysis of interdigitated transducers often relies on phenomenological models to approximate device electrical performance. While these approaches prove essential for signal processing applications, phenomenological models provide limited information on the device’s mechanical response and physical characteristics of the generated acoustic field. Finite element method modeling, in comparison, offers a robust platform to study the effects of the full device geometry on critical performance parameters of interdigitated transducer devices. In this study, we fabricate a surface acoustic wave resonator on semi-insulating GaAs [Formula: see text], which consists of an interdigitated transducer and acoustic mirror assembly. The device is subsequently modeled using fem software. A vector network analyzer is used to measure the experimental device scattering response, which compares well with the simulated results. The wave characteristics of the experimental device are measured by contact-mode atomic force microscopy, which validates the simulation’s mechanical response predictions. We further show that a computational parametric analysis can be used to optimize device designs for series resonance frequency, effective coupling coefficient, quality factor, and maximum acoustic surface displacement.
more »
« less
Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher.
Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?
Some links on this page may take you to non-federal websites. Their policies may differ from this site.
-
-
more » « less
Abstract Glucose transport from the blood into the brain is tightly regulated by brain microvascular endothelial cells (BMEC), which also use glucose as their primary energy source. To study how BMEC glucose transport contributes to cerebral glucose hypometabolism in diseases such as Alzheimer’s disease, it is essential to understand how these cells metabolize glucose. Human primary BMEC (hpBMEC) can be used for BMEC metabolism studies; however, they have poor barrier function and may not recapitulate in vivo BMEC function. iPSC-derived BMEC-like cells (hiBMEC) are readily available and have good barrier function but may have an underlying epithelial signature. In this study, we examined differences between hpBMEC and hiBMEC glucose metabolism using a combination of dynamic metabolic measurements, metabolic mass spectrometry, RNA sequencing, and Western blots. hiBMEC had decreased glycolytic flux relative to hpBMEC, and the overall metabolomes and metabolic enzyme levels were different between the two cell types. However, hpBMEC and hiBMEC had similar glucose metabolism, including nearly identical glucose labeled fractions of glycolytic and TCA cycle metabolites. Treatment with astrocyte conditioned media and high glucose increased glycolysis in both hpBMEC and hiBMEC, though hpBMEC decreased glycolysis in response to fluvastatin while hiBMEC did not. Together, these results suggest that hiBMEC can be used to model cerebral vascular glucose metabolism, which expands their use beyond barrier models.
-
Free energy functionals of the Ginzburg–Landau type lie at the heart of a broad class of continuum dynamical models, such as the Cahn–Hilliard and Swift–Hohenberg equations. Despite the wide use of such models, the assumptions embodied in the free energy functionals frequently either are poorly justified or lead to physically opaque parameters. Here, we introduce a mathematically rigorous pathway for constructing free energy functionals that generalizes beyond the constraints of Ginzburg–Landau gradient expansions. We show that the formalism unifies existing free energetic descriptions under a single umbrella by establishing the criteria under which the generalized free energy reduces to gradient-based representations. Consequently, we derive a precise physical interpretation of the gradient energy parameter in the Cahn–Hilliard model as the product of an interaction length scale and the free energy curvature. The practical impact of our approach is demonstrated using both a model free energy function and the silicon–germanium alloy system.more » « less
-
more » « less
Abstract Background Candidatus Nanohaloarchaeota, an archaeal phylum within the DPANN superphylum, is characterized by limited metabolic capabilities and limited phylogenetic diversity and until recently has been considered to exclusively inhabit hypersaline environments due to an obligate association withHalobacteria . Aside from hypersaline environments,Ca. Nanohaloarchaeota can also have been discovered from deep-subsurface marine sediments.Results Three metagenome-assembled genomes (MAGs) representing a new order within the
Ca. Nanohaloarchaeota were reconstructed from a stratified salt crust and proposed to represent a novel order,Nucleotidisoterales . Genomic features reveal them to be anaerobes capable of catabolizing nucleotides by coupling nucleotide salvage pathways with lower glycolysis to yield free energy. Comparative genomics demonstrated that these and otherCa. Nanohaloarchaeota inhabiting saline habitats use a “salt-in” strategy to maintain osmotic pressure based on the high proportion of acidic amino acids. In contrast, previously describedCa. Nanohaloarchaeota MAGs from geothermal environments were enriched with basic amino acids to counter heat stress. Evolutionary history reconstruction revealed that functional differentiation of energy conservation strategies drove diversification withinCa. Nanohaloarchaeota, further leading to shifts in the catabolic strategy from nucleotide degradation within deeper lineages to polysaccharide degradation within shallow lineages.Conclusions This study provides deeper insight into the ecological functions and evolution of the expanded phylum
Ca. Nanohaloarchaeota and further advances our understanding on the functional and genetic associations between potential symbionts and hosts. -
null (Ed.)Interdigitated transducer devices provide an advantageous platform to study stress-enhanced interfacial phenomena at elevated temperatures but require a thorough understanding of temperature-dependent material properties. In this study, the temperature dependence of the piezoelectric coefficient for gallium arsenide is determined from 22 ℃ to 177 ℃. Experimental scattering parameter responses are measured for a two-port surface acoustic wave resonator at different temperatures and piezoelectric coefficient values are extracted using a frequency-domain finite element method simulation. Device measurements are taken using an interdigitated transducer fabricated on semi-insulating GaAs(100), oriented in the 〈110〉 direction and device resonant frequencies are shown to decrease with increasing temperature. The experimental scattering response is used to reconcile the simulated scattering response and extract the e_14 piezoelectric coefficient, which is shown to increase linearly with temperature. Using the extracted e_14, surface acoustic wave analysis is completed to study the magnitude of bulk stress values and surface displacement over the experimental temperature range produced by a standing surface acoustic wave field. Surface displacement measurements are taken at room temperature using contact-mode AFM, which corroborate the simulation predictions. The modeling results demonstrate an interdigitated transducers potential as an experimental stage to study surface and bulk stress effects on temperature-sensitive phenomena.more » « less
Full Text Available